Richard Orton

I am currently working on the development of a computational framework to model the spread of bovine tuberculosis and foot-and-mouth diseases in British livestock at the Comparative Epidemiology Informatics group within the Faculty of Veterinary Medicine, University of Glasgow. In addition to epidemiology modelling, my main research areas are bioinformatics (where I am involved in the integration, visualisation and analysis of different functional genomics data sets) and systems biology (where I am involved in the computational modelling of signal transduction pathways using ordinary differential equations and the development of associated computational tools and database systems for their simulation and analysis).


Me

Me on the summit of Beinn an Lochan

r.orton@vet.gla.ac.uk


Background

2009->Present
Scientific Programmer
I am currently working on modelling the spread of TB and Foot-and-Mouth in British livestock at the Comparative Epidemiology group, Faculty of Veterinary Medicine, University of Glasgow.
Boyd Orr Centre for Population and Ecosystem Health

2008->2009
Software Developer
Kapital (risk management of financial derivatives) developer using the Smalltalk programming language for the Securitized Products Group, New York.
JPMorgan

2007->2008
Database Engineer
Simulation modelling of the MAP kinase pathway (SIMAP) project
Bioinformatics Research Centre
University of Glasgow

2003->2007
Research Associate
Biochemical Pathway Simulator (BPS) project
Bioinformatics Research Centre
University of Glasgow

2000->2003
PhD Student
Visualising and Exploring Linked Functional Genomic Data Sets in the Yeast Exploration Tool Integrator (YETI)
Biocomputing Research Unit
University of Edinburgh

1999->2000
Genotyper Analyst
Bioinformatics Department
Oxagen Ltd

1996->1999
Undergraduate Student
BSc (Hons) Biochemistry with Biotechnology
University of Birmingham


Publications

Cell fate decisions specified by the dynamic ERK interactome
von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W
Nature Cell Biology, 11: 1458-1464
Featured in Nature Signalling Gateway: ERK signaling: An integrative approach to cell-fate decisions

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway
Orton RJ, Adriaens ME, Gormand A, Sturm OE, Kolch W, Gilbert DR
BMC Systems Biology, Vol 3 Article 100
Highly Accessed

Version control of pathway models using XML patches
Saffrey P, Orton R
BMC Systems Biology 2009, Vol 3, Article 34

A structured approach for the engineering of biochemical network models, illustrated for signalling pathways
Breitling R, Gilbert D, Heiner M, Orton R
Briefings in Bioinformatics 2008, Vol 9 Issue 5, 404-421

Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway
Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR
IET Systems Biology 2008, Vol 2, Issue 4, 173-183

Computational methodologies for modelling, analysis and simulation of signalling networks
Gilbert D, Fuss H, Gu X, Orton RJ, Robinson S, Vyshemirsky V, Kurth MJ, Downes CS, and Dubitzky W
Briefings in Bioinformatics 2006 7: 339-353

Analysis of Signalling Pathways using Continuous Time Markov Chains
Calder M, Vyshemirsky V, Gilbert D, and Orton RJ
Transactions on Computational Systems Biology VI, vol. 4220, pp. 44-67, Springer, 2006

Computational modelling of the receptor tyrosine kinase activated MAPK pathway
Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W
Biochemical Journal: Vol 392 (2) 249-261, 01/12/2005

Analysis of Signalling Pathways using the Prism Model Checker
Calder M, Vyshemirsky V, Gilbert D, Orton RJ
Proceedings of Computational Methods in Systems Biology (CMSB) 2005

YETI: Yeast Exploration Tool Integrator
Orton RJ, Sellers WI, Gerloff DL
Bioinformatics: January 22nd 2004: 20(2): 284-5

YETI: Yeast Exploration Tool Integrator
Orton RJ, Sellers WI, Gerloff DL
Yeast: July 2003: 20(S): S338-S338

Computer-Aided Visualisation of Archaeological Caves
W. I. Sellers, R. Orton, A. T. Chamberlain
CAPRA: November 2001 (3)


Acknowledged In

A unifying framework for modelling and analysing biochemical pathways using Petri Nets
Gilbert D, Heiner M, Lehrack S
Proceedings of Computational Methods in Systems Biology (CMSB) 2007

Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA
Calder M, Gilmore S and Hillston J
Transactions on Computational Systems Biology VII, vol. 4230, pp. 1-23, Springer, 2006.

Stronger computational modelling of signalling pathways using both continuous and discrete-space methods
Calder M, Duguid A, Gilmore S, and Hillston J
Proceedings of Computational Methods in Systems Biology (CMSB) 2006

Reasoning about the ERK signal transduction pathway using BioSigNet-RR
Shankland C, Tran N, Baral C, and Kolch W
Proceedings of Computational Methods in Systems Biology (CMSB) 2005

Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA
Calder M, Gilmore S and Hillston J
Proceedings of Bio-CONCUR 2004


Student Projects

The effect of oncogenic mutations in the ERK pathway
Michiel Adriaens
2007

An interspecies comparison of cell signalling pathways
Jonathan Atkins
2006

BioPathConstruct: a software tool to construct models of biochemical pathways
Elodie Laine
2006

EdFish: a biochemical pathway diagram editor
Tim Fisher
2004


Links

Computational Modelling of the MAPK pathway
Supplementary information on the computational models analysed in the Biochemical Journal paper including links to SBML files, original papers and model pictures.

Modelling the MAPK pathway
Slides from modelling lecture as part of the Computational Methods in Systems Biology MSc module.

Modelling Biochemical Systems with Gepasi
Supplementary information on the computational models analysed in the Gepasi talk including links to Gepasi files, original papers, model pictures and simulation results (internal access only).

MAPK Model Database
Mitogen Activated Protein Kinase (MAPK) Model Database (password required)


Contact

Richard Orton
Comparative Epidemiology Informatics
Institute of Comparative Medicine
Faculty of Veterinary Medicine
University of Glasgow
Glasgow
G61 1QH

Email: r.orton@vet.gla.ac.uk
Tel: 0141 330 2268
Web: http://www.richardorton.co.uk


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